Senior/Principal Scientist – Simcyp (a Certara company)

Closing Date for Applications: Midnight (UK time), Monday 2nd May 2016 

Line of Management: Head of group

Position Type: Full Time

Holiday Entitlement: 25 days, plus statutory bank holidays

Salary: £38,000 - £55,000 per annum dependent on qualifications and experience (plus discretionary bonus, contributory pension scheme, health care scheme etc.)

Location: Sheffield, UK

Job Overview:

We have an immediate opening for a highly motivated scientist with in-depth knowledge and hands on experience of drug metabolism and pharmacokinetics, clinical pharmacology and PK/PD. The successful candidate will assist with the development of mechanistic pharmacokinetic models concerning safety and efficacy of small and large molecules. Identifying and applying applications of modelling and simulation in the clinical pharmacology arena is an essential part of the role.

The candidate is expected to mentor and support junior colleagues, keep abreast of the latest scientific developments and actively engage with peers and clients within industry, academia and regulatory agencies. The candidate will also provide on-going customer support and education/training related to the use of the Simcyp Simulator and act as tutor at workshops. Prior experience of working in drug discovery/development to simulate efficacy and safety of drugs and drug candidates would be an advantage. The post does not include routine laboratory or clinical work.

We offer a unique and exciting mix of academic and  commercial  environments  and  encourage  regular  attendance  at  scientific  meetings  as  part  of our continuous education programs.



  • PhD in pharmaceutical sciences, drug metabolism and pharmacokinetics, pharmacology, computational biology, control or chemical engineering or related fields with more than 3 years of hands-on experience in drug metabolism and pharmacokinetics, PBPK modelling, clinical trial simulation, disease progression modelling, and/or model based meta-analyses;
  • Proven track record of publications in high impact factor journals;
  • Good working knowledge of common tools for pharmacokinetic modelling such as Simcyp, Phoenix, NONMEM, R, MATLAB, etc.;
  • Excellent record of communication skills, as evident by presentation at scientific meetings, and interpersonal and organizational skills.


  • Awareness of R&D process in pharmaceutical companies;
  • Familiarity with various in vitro ADME methodologies and in vitro/in vivo extrapolation techniques;
  • Experience of managing other scientists.

Company Overview:

Simcyp is part of Certara, a company which combines sophisticated research and development informatics with the power of predictive science methodologies to span the drug development spectrum and offer pharma a previously unavailable ‘end-to-end’ solution in the quest for improving human health. The Simcyp team conducts cutting-edge research and provides consultancy, knowledge integration tools, algorithms, modelling solutions and databases (implemented in its globally-recognised Simcyp Population-based Simulator) for a client base of major blue-chip pharmaceutical and biotechnology organisations. Simcyp focuses, in particular, on gathering information required for the modelling and simulation (M&S) of the individual time-course and fate of drugs. We are on course to become the global industry standard, consequently, there is a continuous requirement for high quality people to join us, help in our expansion and share in our success.

Please send your CV, covering letter and the names of two references quoting SPS/May/Certara to:

Email:; OR

Post: Recruitment, Simcyp, Blades Enterprise Centre, John Street, Sheffield, S2 4SU, UK