Running simulation in command line mode

Hi,

I am trying to run simulations from the command line. My final model (.MDL) is a simple one compartment (following) model. I would like to run a simulation with a different dose level from the command line. so I created a dummy table for simulation as .csv file. Now, the question is how I should change the following script (PML) in the model file below to be able to simulate the new dose by command and receive the sim table as an output? 

Hi Amir,

I have attached a project file with a sample simulation. Also, there are a few youtube links that could be of use to you.

 Forum_A_sim.phxproj   444.05KB   243 downloads

http://https://www.y...h?v=daSpOq1mczc

 

http://https://www.y...h?v=4PpZHGAHlsQ

 

 

Hi Amir,

 

I have attached a project file with a sample simulation. Also, there are a few youtube links that could be of use to you. (

)

Forum_A_sim.phxproj

 

 

 

Hi,

 

I am trying to run simulations from the command line. My final model (.MDL) is a simple one compartment (following) model. I would like to run a simulation with a different dose level from the command line. so I created a dummy table for simulation as .csv file. Now, the question is how I should change the following script (PML) in the model file below to be able to simulate the new dose by command and receive the sim table as an output? 

 

test(){

cfMicro(A1, Cl / V, first = (Aa = Ka))

dosepoint(Aa)

C = A1 / V

error(CEps = 28.5596588388192)

observe(CObs = C + CEps * sqrt(1 + C^2 * (CMultStdev/sigma())^2))

stparm(Ka = tvKa * exp(nKa))

stparm(V = tvV * exp(nV))

stparm(Cl = tvCl * exp(nCl))

stparm(CMultStdev = tvCMultStdev)

fixef(tvKa = c(, 0.60176277128161, ))

fixef(tvV = c(, 0.0144284881142417, ))

fixef(tvCl = c(, 0.0299291076746268, ))

fixef(tvCMultStdev = c(, 0.458258322029198, ))

ranef(diag(nV, nCl, nKa) = c(1.0100196, 0.92041129, 0.9488175))

}

 

Best

Amir

 

 

Edited by cradhakr, 08 June 2022 - 02:00 PM.

Hi Cradhakr, 

Thanks for your reply. I think I should elaborate  a bit on my work. I built a popPk for L-dopa. Now, what I am trying to do, is making a platform (such as a website) for physicians to be able to see the simulated PK profile of L-Dopa with different dose levels and various dosing interval. This required that I have four components to be able to run simulations from a command line. which I have them.

Certara Phoenix Assistance

I know how to build this website connecting that to the command line to run simulations. 

The only problem that I have is what I should do in the PML code of my .MDL file to be able to run simulations through command line (without needing to open software). 

I hope I could express my idea more clearly. 

p.s. the youtube links are not accessible. Could you please check their address? 

Hi Cradhakr, 

 

Thanks for your reply. I think I should elaborate  a bit on my work. I built a popPk for L-dopa. Now, what I am trying to do, is making a platform (such as a website) for physicians to be able to see the simulated PK profile of L-Dopa with different dose levels and various dosing interval. This required that I have four components to be able to run simulations from a command line. which I have them.

Certara Phoenix Assistance

 

I know how to build this website connecting that to the command line to run simulations. 

The only problem that I have is what I should do in the PML code of my .MDL file to be able to run simulations through command line (without needing to open software). 

 

I hope I could express my idea more clearly. 

 

p.s. the youtube links are not accessible. Could you please check their address? 

Hi,

I have to check with my technical team on this and get back to you.

Thanks

Mouli