a goody from the BE-wizard. I used to setup Potvin’s model of pooled data (stage 1&2) as:
Fixed: Sequence+Stage+Period(Stage)+Treatment
Random: Subject(Sequence*Stage)
Results agree with reported ones (Example 2) of the paper:
94.12% CI: 88.45–116.38%
Unfortunately EMA wants all effects fixed (which works in the conventioanl setup of stage 1) but in the pooled analysis I got:
“ERROR 11050: Parsing error: The containing term must be in model.”
The core output stops after the partial test; no LSMeans are calculated.
I could run the model in LME – but only if I didn’t ask for the LSMeans (otherwise I got the same error like from the BE wizard).
Results validated against R and SAS (http://forum.bebac.a...try.php?id=9462).
Do you think it will be possible to catch the error (I guess LME passes the results to BE)? Most users are not familiar with LME and are lost when they try to use the BE wizard.
Example project attached.
[file name=Potvin2.phxproj size=2567353]http://www.pharsight.com/extranet/media/kunena/attachments/legacy/files/Potvin2.phxproj[/file]
P.S.: Of course LSMeans are not necessary for the BE analysis. Some regulators will be surprised if the are missing anyhow.
Attached Files
Edited by Simon Davis, 08 January 2019 - 02:39 PM.