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Multiple dose simulation. Does # Points in simulation matter?

Simulation

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#1 abpkpd

abpkpd

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Posted 03 February 2017 - 08:49 PM

I am simulating multiple dose 2 Comp PK Profile for short IV infusions using WinNonlin 7. I noticed that PK Profile changes based on # Points used in simulation. For 1-2000 hr (X axis) comparing 100 vs 2000 # point (6 doses), # 100 showed variable Cmax values between different cycles where as # 2000 appeared to be consistent. I guess this can happen because of large DT. So is there a way to decide appropriate # points based on time scale or dosing regimen?



#2 mittyright

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Posted 07 February 2017 - 01:42 AM

Dear abpkpd!

If you are talking about infusion, the closer is sampling time to the end of infusion, closer the Cmax value to the exact one

Hope it helps,
Mittyright

#3 Simon Davis

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Posted 15 February 2017 - 03:29 PM

Also if you build your model in Phoenix engine instead then you can request a table (under Run options) where you ask the specific times or sequences of times that you would like to have predicted concentrations.

 

  Simon.

 

https://certara-trai...ic-Schedule.pdf







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