Jump to content


Photo
- - - - -

Interesting Target-Mediated Disposition Properties

TMDD IV-Infusion

  • Please log in to reply
No replies to this topic

#1 bwendt@certara.com

bwendt@certara.com

    Advanced Member

  • Administrators
  • 188 posts

Posted 08 February 2017 - 09:59 AM

Here is a contribution from Johan Gabrielsson to our recent webinar on TMDD:

 

He just published a paper in the AAPS Journal on TMDD models where he showed how to apply acute dose disposition data/information to predict the target suppression vs ligand (R vs L), complex versus ligand (RL vs L) and ligand concentration at half-maximal R0 and RLmax (L50).

 

If you are interested, please download a copy of the article:

 

Attached File  Gabrielsson_et_al-2017-The_AAPS_Journal.pdf   1.11MB   718 downloads

 

 

 

Bernd


  • mittyright likes this





Also tagged with one or more of these keywords: TMDD, IV-Infusion

0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users