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[Christopher Mehl]

This is a PK 1 compartment IV bolus model with multiple doses administered on different occasions. 

 

Parameterization: V, Cl

Error model: Multiplicative, with 10% CV

Random Effects: Between Subject Variability 0.3(~55% CV)

Inter-occasion Variability 0.1 (~30% CV)

 

For model translation information, refer to the attached slide deck. The model is run in both NLME and NONMEM in the attached Phoenix project file.

 

In NLME, the model engine is Quasi-Random Parametric Expectation Maximization (QRPEM)

 

For details about QRPEM, refer to Phoenix Help > Contents > Phoenix Model > Phoenix Model Run Modes, Engines, and Output > Phoenix Model Engines > QRPEM.

 

In NONMEM, the model engine is Importance Sampling (IMP) EM.

Attached Files

•  NONMEM to NLME Translation PK 1comp IV bolus with inter-occasion variability IOV.pdf   2.5MB   62 downloads
•  1Comp_IV_Bolus_with_inter_occasion_IOV.phxproj   1.54MB   46 downloads