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Lesson 10: Turnover III - Nonlinear Disposition

PML Saturated Michaelis-Menten Turnover

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#1 bwendt@certara.com

bwendt@certara.com

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Posted 02 March 2017 - 04:27 PM

On March, 2nd we presented a turnover model of an endogenous compound with saturated elimination. We explained how to setup a highly variable multiple dosing scheme in Phoenix WinNonlin.Finally, we compared the results with a simple linear elimination model.

 

Here are the materials:

 

Textual Model file:

 

Attached File  PK32_model.txt   843bytes   446 downloads


Slide Deck:

 

Attached File  PK32_slides.pdf   747.28KB   580 downloads

 

Link to the recording of the webinar:

 

https://certara.webe...8ce887f7819d30a

 

 

 

Bernd

Attached Files



#2 bwendt@certara.com

bwendt@certara.com

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Posted 06 March 2017 - 04:34 PM

There was a flaw in the textual model that we posted: 

 

secondary parameters were not using the typical values of the primary parameters from which they were derived.

 

This has been corrected in the new version that you can download from here:

 

Attached File  PK32_model_2.txt   837bytes   296 downloads

 

Bernd

 







Also tagged with one or more of these keywords: PML, Saturated, Michaelis-Menten, Turnover

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