This is a PK 2 compartment oral model with a covariate relationship between both Volume and Clearance, and a categorical covariate disease state. Disease State is a 3 level covariate (0,1 and 2) linked to both V and Cl. The model is fit using First Order Conditional Estimation (FOCE).
For model translation information, refer to the attached slide deck. The model is run in both NLME and NONMEM in the attached Phoenix project file.
