This is a PK 2 compartment model with multiple IV Boluses and clearance parameterization. Both Plasma and urine concentrations are observed responses, and urine content is assumed to be washed out after each urine observation.
In NLME, the model engine is Quasi-Random Parametric Expectation Maximization (QRPEM). For details about QRPEM, refer to Phoenix Help > Contents > Phoenix Model > Phoenix Model Run Modes, Engines, and Output > Phoenix Model Engines > QRPEM.
In NONMEM, the model engine is Importance Sampling (IMP) EM.
For model translation information, refer to the attached slide deck. The model is run in both NLME and NONMEM in the attached Phoenix project file.
NONMEM to NLME Translation PK 2comp multiple IV bolus Plasma Urine QRPEM IMPMAP.pdf 2.08MB 63 downloads
2Comp_Multiple_IV_Bolus_Plasma_and_Urine_QRPEM_IMPMAP.phxproj 1.53MB 39 downloads