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PK 2 compartment multiple IV bolus Plasma and Urine QRPEM/IMP

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#1 Christopher Mehl

Christopher Mehl


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Posted 04 April 2017 - 09:46 PM

This is a PK 2 compartment model with multiple IV Boluses and clearance parameterization. Both Plasma and urine concentrations are observed responses, and urine content is assumed to be washed out after each urine observation.
In NLME, the model engine is Quasi-Random Parametric Expectation Maximization (QRPEM). For details about QRPEM, refer to Phoenix Help > Contents > Phoenix Model > Phoenix Model Run Modes, Engines, and Output > Phoenix Model Engines > QRPEM.
In NONMEM, the model engine is Importance Sampling (IMP) EM.
For model translation information, refer to the attached slide deck. The model is run in both NLME and NONMEM in the attached Phoenix project file.

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