If anyone has the time to open my attached model (linked below), I am having trouble with the visual predictive check for Plasma. There are 2 compounds (same type of model is being used to compare both drugs).
Could you please help me with my model to get an acceptable Visual Predictive Check for plasma. The Confidence interval bands for the lower interval are not coming up, is there a way to cheat the system due to negative observations.
If you are able to view my model, maybe you can tell me your opinion of the model diagnostics and goodness of fit plots, do they seem acceptable to you, maybe there is a problem with the type of error (multiplicative) that is giving rise to these negative plasma observations in the VPC?
Please assist with my model if possible.
Edited by csheme, 12 May 2017 - 11:24 PM.