This is a PK 3 compartment model with IV bolus administration and clearance parameterization.
In NLME, the model engine is Quasi-Random Parametric Expectation Maximization (QRPEM). For details about QRPEM, refer to Phoenix Help > Contents > Phoenix Model > Phoenix Model Run Modes, Engines, and Output > Phoenix Model Engines > QRPEM.
In NONMEM, the model engine is Importance Sampling (IMP) EM.
For model translation information, refer to the attached slide deck.
NONMEM to NLME Translation PK 3comp IV Clearance QRPEM IMP.pdf 1.31MB 19 downloads
The model is run in both NLME and NONMEM in the attached Phoenix project file.
3Comp_IV_bolus_clearance_QRPEM_IMP.phxproj 2.68MB 15 downloads