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PK 3 Compartment IV Bolus QRPEM/IMP


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#1 Christopher Mehl

Christopher Mehl

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Posted 27 June 2017 - 05:31 PM

This is a PK 3 compartment model with IV bolus administration and clearance parameterization. 
 
In NLME, the model engine is Quasi-Random Parametric Expectation Maximization (QRPEM). For details about QRPEM, refer to Phoenix Help > Contents > Phoenix Model > Phoenix Model Run Modes, Engines, and Output > Phoenix Model Engines > QRPEM.
 
In NONMEM, the model engine is Importance Sampling (IMP) EM.
 
For model translation information, refer to the attached slide deck.
 
 
The model is run in both NLME and NONMEM in the attached Phoenix project file.
 
Attached File  3Comp_IV_bolus_clearance_QRPEM_IMP.phxproj   2.68MB   15 downloads





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