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PK Inhibitory Emax 1 compartment Oral dosing QRPEM/IMP


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#1 Christopher Mehl

Christopher Mehl

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Posted 19 July 2017 - 08:25 PM

This is a 1 compartment PK/Emax model with a single Oral dose and inhibitory PD.

 

In NLME, the model engine is Quasi-Random Parametric Expectation Maximization (QRPEM). For details about QRPEM, refer to Phoenix Help > Contents > Phoenix Model > Phoenix Model Run Modes, Engines, and Output > Phoenix Model Engines > QRPEM.
 
In NONMEM, the model engine is Importance Sampling (IMP) EM.

 

 

For model translation information, refer to the attached slide deck.

 

Attached File  NONMEM_NLME_TRANSLATION_1Comp_Oral_PK_Emax_Inhibitory_QRPEM_IMP.pdf   741.28KB   32 downloads

 

The model is run in both NLME and NONMEM in the attached Phoenix project file.

 

Attached File  1Comp_Oral_PK_Imax_QRPEM_IMP.phxproj   2.24MB   21 downloads






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