This is Population PKPD model. The PK is a 2 compartment extravascular model with clearance parameterization, with multiple Doses (every 12 hours for 84 days). The PD is an Emax model with the effect depending on the cumulative AUC from t=0 to t=t. The Emax is found using the logistic function, ilogit. The overall model is fit using First Order Conditional Estimation (FOCE).
For model translation information, refer to the attached slide deck.
NONMEM_NLME_TRANSLATION_PPK_PD_with_Emax_dependent_on_AUC_FOCE.pdf 791.16KB 73 downloads
The model is run in both NLME and NONMEM in the attached Phoenix project file.
2Comp_Multiple_Oral_Dose_PK_with_Emax_dependent_on_AUC.phxproj 1.59MB 39 downloads