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Nonlinear PK_Oral

Nonlinear Oral Intestinal

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#1 raghava choudary

raghava choudary

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Posted 03 August 2017 - 06:15 AM

Hi all,

 

Can anybody help in obtaining a best fit to the data. The compound follows non-linear PK.

 

with best regards,

 

R

 

Attached File  Plasma PK Modeling_Nonlinear.phxproj   1.32MB   222 downloads



#2 Simon Davis

Simon Davis

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Posted 04 August 2017 - 03:32 PM

Hi Raghav, I looked at your project and it seemed that you just had to refine your initial estimates and then you need to assess your model.  I have done this for you, of the models I tried i believe 2 com with multiplicative error is best on balance; if you look at the model comparer you can se i thas the lowest AIC and generally the best residual plots.  To learn more about model fitting and selection why not take one of our online courses e.g.;

 

 

http://www.certarauniversity.com/lms/index.php?r=course/details&id=26

 

  Simon.

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