Jump to content


Nonlinear PK_Oral

Nonlinear Oral Intestinal

  • Please log in to reply
1 reply to this topic

#1 raghava choudary

raghava choudary

    Advanced Member

  • Members
  • PipPipPip
  • 81 posts

Posted 03 August 2017 - 06:15 AM

Hi all,


Can anybody help in obtaining a best fit to the data. The compound follows non-linear PK.


with best regards,




Attached File  Plasma PK Modeling_Nonlinear.phxproj   1.32MB   242 downloads

#2 Simon Davis

Simon Davis

    Advanced Member

  • Administrators
  • 1,129 posts

Posted 04 August 2017 - 03:32 PM

Hi Raghav, I looked at your project and it seemed that you just had to refine your initial estimates and then you need to assess your model.  I have done this for you, of the models I tried i believe 2 com with multiplicative error is best on balance; if you look at the model comparer you can se i thas the lowest AIC and generally the best residual plots.  To learn more about model fitting and selection why not take one of our online courses e.g.;






Attached Files

Also tagged with one or more of these keywords: Nonlinear, Oral, Intestinal

0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users