5 replies to this topic

[Helmut Schütz]

Dear all,

 

Michael and I updated the Template.

 

New:

• Works in Phoenix 6.4 and 7.0.
   
• Added 4-period 4-sequence designs:
  • TRTR | RTRT | TRRT | RTTR
  • TRTR | RTRT | TTRR | RRTT
    Both are not recommended (confounded effects) and included only for completeness.
• Added the 3-period 2-sequence (partial) replicate design:
  • TRR | RTR (aka “extra reference design”)
    Not recommended since lacking period effects have to be assumed. Since T is not admini­stered in the third period, the treat­ment comparison will be biased in the presence of true period effects. This design should be avoided and included only for completeness.
• Plots of standardized residual vs. subject and model predictions.
   
• Comparison of within-subject variabilities of T and R (full replicate designs only).
   
• Instructions included in the documents folder.

Changed:

• The name of both formulations can be specified (previously only the one of the reference).

The run-time is slightly better than in previous versions but needs patience. Since Phoenix swaps inter­mediate results¹ to the system drive, it will take a while to complete. On my machine (with a fast solid-state drive) execution of the EMA’s reference data set I takes 2:15 minutes.² If you have a hard drive, it may take substantially longer.

 

The template was developed in PHX 6.4.0.768 and tested in PHX 7.0.0.2535. The template was cross-validated with 26 data sets (all designs, up to 360 subjects) against SAS 9.4 (Methods A, B, C), R 3.4.1 (A,  B), STATISTICA (A), and partly (Q&A data sets I and II; Methods A, B) against STaTa 14, SPSS 22, and JMP 10. As usual, use at your own risk.

 

When you execute the workflow Final Conclusions, the outlier analysis (boxplot, etc.) is not automatically performed. Navigate to Analysis > ABEL > Outlier Analysis and execute.

 

Reports of defects and experiences with Windows installed on a hard drive are welcome.

 

 ¹ After execution 4.7 MB (!) in 300 (‼) files. 6 copies each of linmix.exe (292.0 kB) and Dforrt.dll (405.5 kB).

² In R for comparison: 40 milliseconds…

 PS: Balaam’s design (TR|RT|TT|RR) works but was not seriously tested. Should be avoided due to its terrible power characteristics!

Attached Files

•  EMA ABEL Project Template v1.5.phxproj   7.53MB   1336 downloads

[Simon Davis]

Helmut - can you remind me of the best place to get the source reference datasets;  I normally use your site;

 

http://bebac.at/down... Design EMA.xls

 

because I can't seem to find them on the EMA site but maybe I ma missing something obvious?

 

 thanks, Simon.

[Helmut Schütz]

Hi Simon,

 

the data sets are given in the EMA’s Q&A document; there’s a copy in the template’s document folder.

If you are interested not only in them but others check out: https://github.com/H...er/inst/extdata

[j.walczak@polfarmex.pl]

Hi,

I need help to execute the template v1.5 - which worksheet should be selected as Worksheet 1 in "Join RR" step? 

Thx nad best regards, Jarek

[Helmut Schütz]

Hi Jarek,

 

I need help to execute the template v1.5 - which worksheet should be selected as Worksheet 1 in "Join RR" step? 

 

Hhm, once you imported your data and gave the necessary information in Data > 1, 2, 3 you should only execute the last workflow 'Final Conclusions'. Then all mappings should be correctly executed.

 

In the template there is no 'Join RR' object – only Analysis > ABEL > Calculation Steps > Join RR Observations.

If you mean this one:

WS1: Analysis.Calculation Steps.Reference Variability (linear model).Diagnostics

Sort: Diagnostic, Value

WS2: Analysis.Design Conclusions.Data

Sort: DesignConcl, Warning_less_12_TR

 

[j.walczak@polfarmex.pl]

Hi Helmut,

thank you very much. It was very helpful and I have executed the workflow succesfully.

Regards, Jarek