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PKPD: 1 Compartment-IV Infusion - Emax with Baseline, Shape and Effect

NONMEM NLME PKPD Effect

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#1 bwendt@certara.com

bwendt@certara.com

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Posted 20 December 2017 - 12:50 PM

This is a PKPD model with 1 compartment IV infusion for PK and an Emax model with baseline, shape factor and effect compartment for PD.

For model translation information, refer to the attached slide deck. The model is run in both NLME and NONMEM in the attached Phoenix project file.

 

Attached File  NONMEM to NLMR Translation 1comp IV infusion Emax Bl_s_Eff.pdf   1.52MB   77 downloads

 

Attached File  1Comp_IV_infusion_emax_bl_s_eff.phxproj   1.02MB   41 downloads



#2 pharaveej

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Posted 09 February 2018 - 02:16 PM

I am running Phoenix 6.3.0.395 and cannot open the provided .phxproj file because of the version difference. Can you please make it backward compatible? Thanks!



#3 bwendt@certara.com

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Posted 09 February 2018 - 03:04 PM

Sorry, this is a pretty old version that we do not support anymore. The project file can easily be created in earlier versions using the source files. Here you have:

 

the dataset:

 

Attached File  pkpd_link.xls   23.5KB   19 downloads

 

 

the NONMEM control file:

 

Attached File  1c_iv_infusion_emax_bl_s_eff_nonmem.rtf   1.35KB   8 downloads

 

 

the PML code for the Phoenix Model object:

 

Attached File  1c_iv_infusion_emax_bl_s_eff_pml.rtf   36.9KB   10 downloads

 







Also tagged with one or more of these keywords: NONMEM, NLME, PKPD, Effect

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