Dear all,
Presently, I am working on a model to study the effect of the compound on the TNF-alpha concentrations upon LPS challenge. The model equations were based on a report titled " Modelling and design o challenge tests: Inflammatory and metabolic biomarker study examples", authored by Johan Gabrielsson et al.
I observed following results
- Identifiability issue of IC50.
- The IPRED values were close enough to the observation but the PRED values were increased upon increased upon the increase in dose.
Kindly, help me if there was any mistake in the PML code. PK_PD LPS indiced TNF_alpha.phxproj 911.6KB 352 downloads DV,IPRED and PRED vs Time1.tiff 400.88KB 375 downloads
DV,IPRED and PRED vs Time1.tiff 400.88KB 375 downloads
Attached Files
Edited by santosh kumar, 05 February 2018 - 01:43 PM.