Presently, I am working on a model to study the effect of the compound on the TNF-alpha concentrations upon LPS challenge. The model equations were based on a report titled " Modelling and design o challenge tests: Inflammatory and metabolic biomarker study examples", authored by Johan Gabrielsson et al.
I observed following results
- Identifiability issue of IC50.
- The IPRED values were close enough to the observation but the PRED values were increased upon increased upon the increase in dose.
DV,IPRED and PRED vs Time1.tiff 400.88KB 171 downloads
Edited by santosh kumar, 05 February 2018 - 01:43 PM.