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ABEL and Assessing the Type I Error

ABEl TIE alpha replicate

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#1 Veronika Trushko

Veronika Trushko

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Posted 01 March 2018 - 12:31 PM

Hello! Dear all, I need some help with replicate design.

Is it common practice to iteratively adjust α (Type I Error)?

is there an information about this in the guidelines?

And can I adjust α using Phoenix winnonlin?
 

 


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Best regards,

Veronika


#2 Helmut Schütz

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Posted 17 March 2018 - 04:07 PM

Hi Veronika,

Is it common practice to iteratively adjust α (Type I Error)?


No. In the meantime a few companies do it regularly. If your estimated CVwR is outside the “critical range” of ~22–43% you don’t have to worry about an inflated TIE anyhow.

 

is there an information about this in the guidelines?


No.

 

And can I adjust α using Phoenix winnonlin?


Theoretically yes. Though I never tried it and would not recommend it. I guess it would be as least as time-consuming than in SAS – which is easily >1000times slower than by means of the R-package PowerTOST, function scABEL.ad().


 Best regards,
Helmut
https://forum.bebac.at/





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