3 replies to this topic

[dixitv77]

Hello all,

I am modeling a pre-clinical PK-PD data set that fits the the indirect model III i.e. stimulation of kin.  The PD data is normalized to vehicle treated group and is expressed as % change from baseline.

Next I need to link the PD model to a tumor growth inhibition model using the user defined modeling feature.

I was wondering if anyone can help me with a PML code to link the IDR model  III to tumor growth inhibition model where the stimulation of PD response causes tumor cell death.

I am using Phoenix v 8.0 to model this data.

Thank you.

Vaishali Dixit

Edited by dixitv77, 25 April 2018 - 03:30 PM.

[bwendt@certara.com]

Hi Vaishali,

 

can you share your project file. If it has confidential data you may want to send it to support@certara.com.

 

 

Bernd

[dixitv77]

Hi Vaishali,

 

can you share your project file. If it has confidential data you may want to send it to support@certara.com.

 

 

Bernd

I can remove any identifiers and send the file to support@certara.com

Should I cc you as well?

[shekhar.udct@gmail.com]

Hi Bernd, 

 

Can you please share the phoenix file or the code for the problem asked by Vaishali. 

 

Regards

 

I can remove any identifiers and send the file to support@certara.com

Should I cc you as well?

Hi Vaishali, 

 

If you got the answer for this model can you please share the code for the model. 

 

Thank you very much, 

 

Shekhar

 

Hello all,

I am modeling a pre-clinical PK-PD data set that fits the the indirect model III i.e. stimulation of kin.  The PD data is normalized to vehicle treated group and is expressed as % change from baseline.

Next I need to link the PD model to a tumor growth inhibition model using the user defined modeling feature.

I was wondering if anyone can help me with a PML code to link the IDR model  III to tumor growth inhibition model where the stimulation of PD response causes tumor cell death.

I am using Phoenix v 8.0 to model this data.

Thank you.

Vaishali Dixit