Hi, Phoenix Support,
I recently came across this error message when I performed superposition on version 7.0.
"Specified cast is not valid."
How can I get it fixed?
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Posted 03 May 2018 - 08:51 PM
Hi Shu-Pei, this isn't really the support portal but a forum for users to discuss models etc.
Next time I'd email support with your project illustrating the problem; and if this doesn't help that may still b ethe best approach. However it happens I just saw this note whilst researching another case;
Posted 03 May 2018 - 09:23 PM
Thank you for your response Simon, My apology, if it is not an appropriate post here, please remove it. Best regards, Shu-Pei
EDIT by Simon DAVIS
Full Quote removed as it just makes the thread unnecessarily long.
I'll leave the post as it may prove helpful to another user - I was merely pointing out that for a software error message like that you would typically get a quicker/more detailed response from Support@Certara.com.
Edited by Simon Davis, 04 May 2018 - 04:50 AM.
Posted 18 December 2020 - 12:18 PM
In NCA-Nonparametric superposition method, how to give an input for initial dose @ 0 hr (for eg., 10mg), then loading dose (20mg) @ day 7 followed by constant maintenance dose (20mg) every month, your response is highly appreciated.
Posted 18 December 2020 - 01:45 PM
Dear Sundar, use the NPS option for variable dosing, be sure you complete the true administered dose. See attached that assumes your unit of time is in days. But honestly i would try to build and fit a model so you can perform simulations that I think will give you greater confidence in the predictions.
You should also ask yourself what it is you expect to obtain from the simulatlon. Is it just a 'pretty' line of peaks and troughs or do you wnat to estimate exposure with Cmax and AUC on particular days? Perhaps confirm you sampling schedule will be adequte in a future trial etc.
Posted 20 December 2020 - 09:39 AM
first dose should always be recorded as the start time of dosing so time=0.
everything else is relevant to that so, for example the end time of a 30 minute indusion would be 0.5 hours if you were woking in time units of hours, with the start time be 0.
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