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Bayesian posthoc estimates


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#1 Roland123

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Posted 25 June 2018 - 02:30 PM

Dear All,

 

is there a method to perform a bayesian posthoc estimation of individual pharmacokinetic parameters in Phoenix/NLME that would be comparable to what is achieved in NONMEM using the

 

$est maxeval=0 posthoc

 

command?

 

I recently saw that approached being used to evaluate if experimental PK observations could

be described by e.g. a literature derived model.

 

Many Thanks,

Roland

 

 

 



#2 Ana Henry

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Posted 25 June 2018 - 05:11 PM

Dear Roland,

From Phoenix version 7.0 onwards, the posthoc estimates (EBEs) are in a worksheet in the output by default  (see image posthoc.gif).  In previous versions, you can request posthoc estimates using a table statement in the run options (see dataposthoc.gif).  The output will be labeled Table01.

 

Hope this helps,

Ana

Attached Thumbnails

  • posthoc.GIF
  • dataposthoc.GIF


#3 smouksassi1

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Posted 26 June 2018 - 04:03 PM

Dear All,

 

is there a method to perform a bayesian posthoc estimation of individual pharmacokinetic parameters in Phoenix/NLME that would be comparable to what is achieved in NONMEM using the

 

$est maxeval=0 posthoc

 

command?

 

I recently saw that approached being used to evaluate if experimental PK observations could

be described by e.g. a literature derived model.

 

Many Thanks,

Roland

assuming you accepted all final estimates as initial you can only do the post hoc part by having N iter: 0

 

note that depending of methods used e.g. FOCE-ELS the individual posthoc are part of the algorithm versus the FO algorithm where we had to really do a post hoc step at the end.

 

There is no equivalent to NOPOSTHOC option so you always get the posthoc steps and parameters in phoenix nlme. 



#4 Roland123

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Posted 27 June 2018 - 06:05 AM

Many thanks for your answers, much clearer now.

Best Regards

Roland






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