Dear Members of Certara Forum
I have an issue during the development of popPK modeling. I tried to fix the parameters that have large ETA shrinkage to zero. However when I fixed it to zero, the model excution always failed with following error message : out of range final -LL value : 1.0E+70
In NONMEM, I can fix the ETA like this example code :
$OMEGA
0.04
0.04
0 FIX
How can I handle this issue?
And, is there the way to check ETA bar and its p-value in NLME? (I have checked it in manual)
I have an issue during the development of popPK modeling. I tried to fix the parateres that have large ETA shrinkage to zero. However when I fixed it to zero, the model excution always failed with following error message like this : out of range final -LL value : 1.0E+70
In NONMEM, I can fix the ETA like this example code :
$OMEGA
0.04
0.04
0 FIX