Dear all
I am interested in quantitatively comparing the results of different POPPK studies for a certain drug. Each study reports the value of the pharmacokinetic parameter (e.g. clearance) and the standard error of estimated clearance, the value of estimated inter-individual variability in clearance and its standard error.
Q1) How can we judge the superiority of those models based above parameters i.e.
Model A HIGH IIV: CL= 1 L/kg, SE in CL=0.05, (OMEGA)^2=0.55 IIV 74%, SE OF OMEGA=0.001
OR
Model B High imprecision in IIV estimation: CL=1.2 L/KG SE in CL=0.04, (OMEGA)^2=0.02 IIV 14%, SE OF OMEGA=.06 (RSE 300%)
Q2) How can we present all these data together graphically? any examples?
Many thanks