I know there have been several discussions around extravascular modeling and bioavaliability. However, I would like to clarify and confirm my understanding on how Phoenix handles bioavailability parameter:
- While using the in-built model for extravascular dosing - say for oral or SC absorption, unless the user specifically edits graphically or textually and inserts the bioavailability (F) parameter, Phoenix assumes it to be 1 or 100%?
- If edited graphically, i.e. say checking the box for bioavailability in the absorption compartment the parameter has to be specified in the parameter block in the code by editing it textually as well.
- And lastly, instead of checking the bioavailability box for the absorption model, can we code it in the equations directly? Can you share the example equations as to how will that look say for 1 CM model with oral absorption? For example one could multiply the input/dose with F; however with Phoenix since we generally use a dosing sheet, how would this work?
Thank in advance for your response and patience in addressing these most likely repetitive questions.