2 replies to this topic

[wrubas]

Dear All,

 

I need some help with modeling passive and active permeability across Cac-2 cells and in the presence of inhibitor. I attach a paper where this was accomplished in NONMEM. Since I am not familiar with NONMEM I was trying to set it up in PHOENIX. However, this also proves challenging for me.

I attached the original paper and my data table and model structure attempt.

 

Thanks for your support.

 

 

Attached Files

•  P-gp_Kinetic modeling of passive transport and active efflux of a fluoroquinolon across Caco-2 cells using compartmental approach in NONMEM. Gonzales-Alvarez et al. Xenobiotice (2005) .pdf   589.95KB   1018 downloads
•  Gonzales alvarez data.xlsx   30.01KB   415 downloads

[Simon Davis]

Werner, are you able to upload your project/model code so we can comment on the direction you've taken so far and guide you better?

 

thanks, SImon.

[wrubas]

Werner, are you able to upload your project/model code so we can comment on the direction you've taken so far and guide you better?

 

thanks, SImon.

Hi Simon

 

Attached please see what I have at the moment.

Thank you for your help.

 

Werner

Attached Files

•  Active_Passive Permeability model.phxproj   177.3KB   370 downloads