1 reply to this topic

[William R. Wolowich]

has anyone been able to use the stop early function? It never seems to work for me.

[Simon Davis]

Hi William, sorry for the delay, I was trying to find an exmaple that ran long enough to interupt.  i found one in the examples folder;  C:\Program Files (x86)\Certara\Phoenix\application\Examples\NLME

 

Midazolam_Circadian_IOV_TwoEpsilon_Estimation_VPC

 

I ran the first model in that project and performed the right click, and although there is a long pause it does indeed stop.   

Note that for now it first tries to complete the current iteration of optimization then, if some standard error are requested, calculate standard error and finally prepare all things for the output. It may look like it is doing nothing however it is preparing the results.

 

To check if that button is working, please look into Overall sheet; the RetCode is 6.

 

alternatively if you look at the Core Status then you'll see something like the below. 

 

Hope that helps,     Simon.

 -loglike at initial solution
 after initial stabilization =  -7361.3048690289552     

 MANUAL STOP
 User pushed stop button in UI


 Starting std error computation

 Warning: Hessian based standard error
 computation failed in Cholesky factorization step
 of numerical Hessian of -2LL function
 infohess from dpotrf =          12
 Sandwich std error computation thus also fails

 Engine Convergence Summary:

 Convergence failed

 OPTIF9 ITRMCD value on last iteration=           6
 NLME7 return code=           6
 RUN MANUALLY STOPPED BEFORE CONVERGENCE
 

Edited by Simon Davis, 22 November 2018 - 03:34 PM.