Dear all,

I have a question about the calculation of partial AUC using linear up log down method. I am wondering if anyone could help with that.

In one of my studies, the Tlast is about 23.96 hr. To calculate AUC0-24, we used lambda z and intercept to get the predicted C24h, which is a little higher than the observed Clast. I thought WNL should use linear method for the calculation of AUC23.96-24h since the concentration is increasing but it looks like WNL used log method for the calculation. I am a little confused. I searched the guide but didn't anything about that. I am using Winnonlin 7.0.

Thanks,

LLLi