Anyone tried modelling turnover model using the response data which is difference of drug treated and vehicle treated animals. Baseline in this case is zero. There is case study PD28 in Johan Gabrielsson/Dan Weiner book 'PK&PD data analysis: concepts and applications' which is similar to this. That case study describes Winnonlin code in it. Can anyone think of PML code equivalent of that code please? It appears that we need to have initial condition that need to be set by sequence statement and following is my try but now working:
Edited by Pradeepsharma, 07 April 2019 - 12:49 AM.