1 reply to this topic

[mvanzutphen]

Hi,

I'm working on an NCA and the client asks to implement some LLOQ rules, I would like to add PK concentration column with the substituted values in my dataset.

 

1.LLOQ before Tmax = LLOQ/2

2. first LLOQ after Tmax = LLOQ/2

3. all subsequent LLOQ values should be missing

LLOQ = 45

 

I'm using PHX 8.1 and struggling with the BQL Rules option (never had to use it before).

Attached is a subset of the data.

 

Could you please advize on how to fill in the BQL rules?

 

p.s. the client data shows LLOQ/2 for CONCN when CONCT(text) <LLOQ, but now they want to implement the new rule but not update their dataset.

 

Thanks very much in advance

 

Mariëlle  sel variables, properties.xls   194.5KB   445 downloads

[Simon Davis]

Mariëlle, I wasn't sure but I think this will get you what you /your clinet wants.  the sample data set has some interesting things. e.g.

 

1) do you really want to assign a numeric value to time zero e.g predose?

 

2) assigining numeric conc values pre Tmax means you won't have an estimate for tlag.

 

3) I see the data has a late Tmax, but not very much data to really test if I am setting up the rules correctly for later samples.

 

 Simon

 

PS next time posting an actual  project would be easier.

PPS this is a v81 project but rule is also shown in this screenshot

 

Attached Thumbnails

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Attached Files

•  Marielle_BQL.phxproj   511.08KB   470 downloads

Edited by Simon Davis, 19 June 2019 - 01:06 PM.