Mixed absorption modeling
#1
Posted 22 August 2019 - 10:14 AM
#2
Posted 26 August 2019 - 10:46 AM
I'd recommend to look into the other posts where ilogit and its application is discussed
https://support.cert...etween-0-and-1/
support.certara.com/forums/topic/964-modeling-and-simulating-fraction-metabolized/
I beleive the correct way would be
dosepoint(A1, duration=(D), bioavail=(FR))
dosepoint(Aa, bioavail=(1-FR))
stparm(FR = ilogit(THETA5 +nFR ))
regarding second question - it is difficult to say. We see that Theta6 has some unplausible high value. Is that intended?
What do your diagnostic plots say? How far are your results from good fit?
Since including data regarding metabolite you are adding some info into the model, the estimates of the parent thetas/etas also could change, so you can try to fit it simultaneously ?
Simon
#3
Posted 18 September 2019 - 01:39 AM
Dear Simon
Edited by gwchoi, 04 November 2019 - 04:22 AM.
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