2 replies to this topic

[Graham Blakey]

I am working with a dietary supplement that increases the systemic amount of several amino acids (aa) above baseline values.  The analysis requires estimation of incremental AUC (AUCi)  and net incremental AUC (net AUCi).  I have a baseline value for the aa only, there is no threshold value.  The drug effect (model 220) option in NCA allows the input of a baseline value and provides as output the parameters outlined below

 

AUC_Above_B

Area under the response curve that is above the baseline (dark gray areas in the above diagram).

AUC_Below_B

Area that is below the baseline and above the response curve (combined blue and pink areas in the above diagram).

 

Is AUC Above B  equivalent to AUCi? Can net AUCi be estimated as

[AUCabove  B] - [AUC below B]? See Figure 11 (c & e) in the attached paper discussing glycemic index for reference of what I am looking to estimate.

Attached Files

•  Glycemic_index_methodology.pdf   558.9KB   570 downloads

Edited by Graham Blakey, 28 October 2019 - 06:02 PM.

[bwendt@certara.com]

Graham,

 

the drug effect model in NCA calculates 3 values: 

 

 

Here:

AUC_Above_B accumulates all areas that are above the baseline, excluding  any areas below the baseline

AUC_Below_B accumulates all areas that are below the baseline, excluding any areas above the baseline.

AUC_Net_B calculates the difference between these two values.

According to figures 11 c & e:

the black areas in figure 11 c)  represents AUC_Above_B,

the white area between the two black areas in figure 11 c) represents AUC_Below_B

and figure 11 e) represents AUC_Net_B.

 

Hope, this makes sense. Let me know if there are further questions.

 

Bernd

[Graham Blakey]

Excellent, Thanks Bernd for the clarification