We are looking to build a 3 compartmental model for assessing compound uptake into the brain. We have plasma and brain data for the compound which shows a tri-exponential decline. I have gone through some of the courses offered by Certara but only learnt how to model the plasma data. I have seen there are ways of adding Cobs in the graphical model but dont know how to get the software to understand which Cobs belong to the plasma data (central) and which belongs to the brain data.
Would really appreciate your support and guidance on this issue.