Hi Phoenix WNL community,

I am running analysis where AUC0-10h is a required parameter, with samples taken at 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 7, 8, and 10 hours.

I understand that lambda_z is used to estimate the concentration at the 10 h time point for any instances where there is a bleed time deviation (and therefore there is not an observed concentration exactly at 10 h), and therefore AUC0-10 will not be estimated for any instances where:

a) there is a bleed time deviation at the 10 h time point, and

the elimination rate constant was not estimable

However, for one profile there was no deviation at the 10 h time point but AUC0-10 has not been estimated. I cannot work out why this is. I note that there are only values above the LLOQ at the 0.5, 2, 4.5 h, with BLQs from 5 h onwards... could this be why?

Thanks for any help with this!