I have come across an - may be quite an general - issue, namely, how to (best) derive NCA parameters when I have sparse data available?
For instance I have densely sampled drug concentrations available in adults and sparse data in pediatric patients.
1.) My initial idea was to build a POP-PK model using all available data from the adults and pediatric patients and then to use individual simulations of the young to derive the PK parameters via NCA from those simulations.To be consistent with the PK parameter derivation via NCA for the adults and pediatrics, I could also use individual simulations for adults and pediatrics alike.
- Does that procedure makes sense to you?
- How do I get the individual simulations in to the NCA analysis within Phoenix?
2.) I have now also come across a procedure for obtaining PK parameters of sparsely sampled PK data by empirical bayes estimates (EBE).
- How does the procedure using EBEs work?
- How do I perform the calcualtions using EBEs in Phoenix?
- Which procedure is better - indvidual simulation + NCA or PK parameters based on EBEs?
Thank you very much in advance and