I am working on a small molecule with enterohepatic recycling on pharmacokientic study after extravascular administration. However, the model fitting and CV% seems good for pharmacokinetic parameters except clearance for central compartment (always gave the negative values)!!
I have also tried transition model, but all of the model i tried always gave me the negative value for central compartment clearance value (graph fitting and CV% always are great).
Does anyone can explain this issue?
Please check my models and results, I am looking forward to your response!!! Thank you!!!!
Edited by Xiuqing Gao, 19 December 2019 - 09:41 PM.