Seeking help in linking the following
Time course of RO of agonist in the presence and absence of an antagonist by following steps.
seeking help with step 3 simulation of time course of RP of an agonist A where agonist A and antagonist B plasma concentrations are declining with time:
- Simulate PK (c vs t) for A (agonist), 1 compt open model
- Simulate PK (c vs t) for B (antagonist), 1 compt open model
- Linking these two PK profiles to generate time course of RO below Receptor Occupancy, RO (on the left hand) where, where, Ki (X = 1.25 nM (affinity for agonist A) and Ki (Y = 5 nM) affinity, for antagonist are known
RO, when X and Y are fixed at 1.25 and 5 nM, respectively, A and B are agonist and antagonist concentrations from 1 & 2 above.
RO = -----------------
A + X (1 + B/Y)
Thank you very much!