I am interested in learning how to perform a population-based meta-analysis of drug PK.
For the drug I have selected, I have the following literature data thus far:
(1) 1 literature report that provides 10 individual parameter estimates. The raw concentrations are not reported. I simulated conc vs. time profiles for each individual.
(2) Several literature reports with a mean concentration-time profiles. I have digitized these.
In the data set I have both the individual and aggregate conc-time profile (with study size) in the data set.
I'm not sure how to begin to code for the aggregate data. I'm hoping for help to understand the process.
See attached project. Meta PK.phxproj 1.23MB 56 downloads
Edited by tbensman, 24 April 2020 - 08:53 PM.