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population-based meta-analysis of drug PK

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#1 tbensman



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Posted 24 April 2020 - 08:05 PM

I am interested in learning how to perform a population-based meta-analysis of drug PK.




For the drug I have selected, I have the following literature data thus far:




(1) 1 literature report that provides 10 individual parameter estimates. The raw concentrations are not reported. I simulated conc vs. time profiles for each individual.




(2) Several literature reports with a mean concentration-time profiles. I have digitized these.




In the data set I have both the individual and aggregate conc-time profile (with study size) in the data set.


I'm not sure how to begin to code for the aggregate data. I'm hoping for help to understand the process. 




See attached project. Attached File  Meta PK.phxproj   1.23MB   56 downloads

Edited by tbensman, 24 April 2020 - 08:53 PM.

#2 bwendt@certara.com


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Posted 27 April 2020 - 07:20 AM

Population-based meta analysis requires you to reproduce the population response. I will conduct a webinar in May to demonstrate these steps:


Rebuilding a Population PK Model From a Literature Reference

Often you are working on data from an existing compound where literature data exists. This webinar will help users build up a population PK model from a literature reference.


Register Now!



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