I used the Phoenix Model to do a population PK analysis for multiple different subjects and for some reason the population predicted profiles, labeled PRED, are slightly different for each subject.
I understand the the IPRED values should be different because they are individual concentration predictions for each subject but shouldn't the PRED values be exactly the same for each subject?
This graph from my oral pop pk model shows the overlaid PRED curves from each individual and the PRED curves are slightly different.
This graph from my oral and IV linked pop pk model shows 6 individual graphs with the OBS value, IPRED curve (red) and PRED curve (blue). If you see the graphs labelled 1 and 2, they are both sampled to 24 h but both have different PRED curves.
Why are the PRED curves not the same for each subject?
Edited by adityark, 12 May 2020 - 06:27 AM.