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PK parameters in Steady state

Cmin ss Cmax ss steady state PK

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#1 Renee



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Posted 13 May 2020 - 07:50 AM



Can someone tell me how to calculate the PK parameters (e.g. Cmin, Cmax) of steady state for a repeated dose PK study? 



#2 Simon Davis

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Posted 13 May 2020 - 08:25 AM

Hi Renee, these are derived for you automatically when you run NCA as a steady state model.  you do this by entering the dosing interval (in the same units as time) in the tau column.  remember if you have several 'pk days' you will need to identify them as a sort.

if you're still stuck feel free to attach an example project


Edited by Simon Davis, 13 May 2020 - 08:26 AM.

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