I was trying to model some data in which the patients continuously take their drug daily before the time of enrollment in study and once a day is taking throughout the study period. and at the time of study start they were assumed to be on steady state. On the first visit pre dose sample was taken and then dosed and 2 hr and 6 hr. time point was recorded. Additional blood samples were taken on their subsequent visit ever 4 weeks upto 28 weeks (one blood sample after dose in clinic). I used your recent webinar to map steady state and additional dose altogether. Here is the link.
My model is running only with one compartment additive error model with return code 1. when i am trying any other model it is showing for certain id's steady state not reached unable to execute. Some time it is showing for certain Id's Error (Model.C): non-finite_ypred. One more thing I observed with one compartment additive model is the omega table showing very high values like ncl = 46.30, nKa = 61 and NV = 6.2. I am using initial estimates from literature.
When I am looking doses output then it is showing three doses at 24 hours. I am also not getting this.
We want to predict interoccassion variability in this project. so, before adding this as a covariate wanna make sure about base model. Theta table for one compartment additive is also fine with displaying all %CV values within 20%. I can't attach full project and excel sheet but I am attaching a part of excel and mapping details for SS and addl.
Edited by veenu.bala, 16 June 2020 - 04:19 PM.