3 replies to this topic

[mike.liu]

Hi,

 

I'm working on using Phoenix WinNonlin 8.2 on a PKPD model project. The model scheme is in the attached figure. I used IDR in Phoenix model to work out the part in the red box. To move forward, it seems I need to use PML codes. Could you give me some guidance on this? I've also include my IDR codes below. 

 

Thanks,

 

-Mike

 

 

test(){

deriv(E = Kin * (1 + Emax * C / (C + EC50)) - Kout * E)

cfMicro(A1, Cl / V, first = (Aa = Ka))

dosepoint(Aa)

C = A1 / V

sequence{E = Kin / Kout}

error(EEps = 0.1)

observe(EObs = E * (1 + EEps))

stparm(Ka = tvKa)

stparm(V = tvV)

stparm(Cl = tvCl)

stparm(Kin = tvKin)

stparm(Kout = tvKout)

stparm(Emax = tvEmax)

stparm(EC50 = tvEC50)

fixef(tvKa(freeze) = c(, 3, ))

fixef(tvV(freeze) = c(, 47.584317, ))

fixef(tvCl(freeze) = c(, 1.6311257, ))

fixef(tvKin = c(, 0.00062, ))

fixef(tvKout = c(, 0.0066, ))

fixef(tvEmax = c(, 803, ))

fixef(tvEC50 = c(, 2.9, ))

}

Attached Thumbnails

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[mike.liu]

I made some progress but the model can't go through. There is an error message. Please help take a look on the Phoenix file and error message here.

Thanks!

Attached Thumbnails

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Attached Files

•  precursor model.phxproj   419.37KB   436 downloads

[Ana Henry]

Hello Mike,

I think the problem is that you have a 2 EEps parameters (the same name) for both observation blocks.  I renamed one EEps to EEps2 and the model seems to run fine.  Give it a try.

 

Ana

[mike.liu]

Hi Ana,

 

It worked!

 

Thanks,

 

Mike