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ABE using GLM

BE ABE Crossover

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#1 sirikalyan

sirikalyan

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Posted 25 June 2020 - 06:23 PM

Hi,

I want to use Phoenix for performing Average Bioequivalence (ABE) of a 2x2x2 design using the GLM model proposed by FDA in their guidance.

While I can use subject as a random effect, in Phoenix and perform ABE, this would become mixed effect model.

 

Can you please let me know how to use subject nested in sequence as a fixed effect while using phoenix.

 



#2 Simon Davis

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Posted 26 June 2020 - 05:43 AM

Delete Subject(Seq) from random tab.

 

And add it to the end of Fixed Effects.

 

Remember it is case sensitive.

Attached Thumbnails

  • random.jpg
  • fixed.jpg

Edited by Simon Davis, 26 June 2020 - 05:45 AM.


#3 Simon Davis

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Posted 09 July 2020 - 02:52 PM

Phoenix uses the same algorithm with or without random effects.
- it is like PROC MIXED, whether there are random effects or not.

Simon.

edit: actually to clarify if all effects are fixed then GLM is feasible
‚Äč
For the case when subject only is random and the design is not replicated it is still GLM, you may read a more detailed discussion on this thread https://forum.bebac....id=19512#p19524

Edited by Simon Davis, 15 July 2020 - 12:30 PM.






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