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Bioequivalence Workflow Execution Error 11016


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#1 DFrancombe

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Posted 22 July 2020 - 05:12 PM

Hi all,

 

I’m working on a 3 period, 3 treatment, crossover PK study; using the bioequivalence module to determine BE (Test/Reference) (Test/Comparator) I’m able to execute the run where I have an equal number of observations per treatment.  Where I have an uneven number, LSMs are not estimable and I receive the error message: "ERROR 11016: Numerical problem when computing satterthwaite df."

 

I suspect the issue/answer is within the information above but if anyone could shed any light on this, I’d be very grateful.

 

Thanks in advance,

Danielle

 



#2 Simon Davis

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Posted 27 July 2020 - 07:37 PM

Is it possible you can share your project ?

I'm not sure if Phoenix is defaulted to the replicated model (probably is), or if you made other changes.  It could be the expected instability with a partial replicate model.



#3 Helmut Schütz

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Posted 28 July 2020 - 10:18 PM

Hi Danielle,
 
from your description
 

… 3 period, 3 treatment, crossover PK study […] to determine BE (Test/Reference) (Test/Comparator)

 
your design is not clear to me. Do you have a higher-order crossover (e.g., 3×3 Latin Squares like TCR|CRT|RTC or a 6-sequence Williams’ design)?
 
If yes, you should set up data wizards to obtain two data sets in Incomplete Block Designs (i.e., in the first you exclude R and in the second C). Then perform two separate analyses, one T vs. C and one T vs. R. See also the Vignette of the R-package PowerTOST.


 Best regards,
Helmut

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