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can't computed the CV% and 95%CI in the final model

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#1 1711197384@qq.com



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Posted 20 August 2020 - 08:41 AM

Hi, everyone,

I have built a  2-compartment models. after the stepwise program, and then I got the final model with some covariates.However, in my theta output, I am not getting any stderr or %CV estimates.  What should i do next.

1. I known i can change the stderr method such as fishor, but this method has  low accuracy, some parameters' cv% was much high, and confidence interval including 0, so when i write article, this result is acceptable?

2.on the other hand, when i "accpeted all fixed and random" in the final model, and then run again untill i got the cv%, this method was corrected?(because this model including covariates,so maybe the OFV was changed, which different in final model )

3.if i can changed the algorithm in the final model?(such as QRPEM), and If I do this, do I need to run from the basic model?

4.the CV% and 95%CI in the bootstrap(1000 simulation,can it be substituted as CV% in the final model  when I write article, Is there literature support?


I really need help,

have a good day.


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