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No simulated conc vs time profile for oral administration

NLME Population PK Phoenix

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#1 adityark

adityark

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Posted 24 August 2020 - 06:44 AM

Hello,

 

I created a model to simultaneously predict the concentration time profile for a parent compound and metabolite for three different routes of administration (IV, PO, inhalation) using the NLME Pop PK in Phoenix.

 

The model with IV and Inhalation is working as intended which is labeled as "IV and Inh THC 11OHTHC FO" in the attached file.

 

When I add the oral route of administration "PO, IV and Inh THC 11OHTHC FO", there is no simulated profile for the parent or metabolite via the oral route.

 

Does anyone have any ideas why this is happening?

 

Thank you,

Adi

 

 

Issue was solved by changing the absorption equations.


Edited by adityark, 24 August 2020 - 07:01 AM.

  • Simon Davis likes this

#2 Simon Davis

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Posted 24 August 2020 - 12:04 PM

glad you solved it, note your project was not attached. Simon







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