I am trying to build a transit compartment model to fit the plasma PK with two peaks especially at high dose groups. It is reported that transit compartment is a good choose. I add a transit statement. But unfortunately couldn’t fit data. No effect was observed when I tried to adjust mtt, ktr and ntr. Sounds like there is a glitch.
It will be appreciated if you can help in fitting the PK data to transit compartment model. I am attaching project file with existing mode for only high dose PK.