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Co-modeling of multiple observed data profile


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#1 dinhbt1988@gmail.com

dinhbt1988@gmail.com

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Posted 16 November 2020 - 03:53 AM

Hello,

 

I am working on PK modeling of drug concentrations in both plasma and saliva. Could you please help to give instruction on how to model drug concentration in multiple observed compartments simultaneously? Thank you!


Edited by dinhbt1988@gmail.com, 16 November 2020 - 03:53 AM.


#2 Simon Davis

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Posted 16 November 2020 - 08:17 AM

The easiest way to do this is create your dataset to have a column per observation location.  Have a look at the 2 dose point example in the manual

 

https://onlinehelp.c..._Creating_a_two

 

the principle is the same for 2 or more sample points.

 

  I think there maybe an example too from one of the PML webinars, but have a try and post your project if you get stuck.

 Simon.



#3 bwendt@certara.com

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Posted 16 November 2020 - 08:32 AM

There is one example among the PML School webinars where we show how to deal with two observations: parent and metabolite:

 

https://support.cert...olite-kinetics/

 

Please take a look at the recorded session where we show the steps to build this model from scratch.

 

Bernd






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