Thank you for the quick answer. However, I am still confused, I do not know how to implement the NCA Model 202 for the infusion. It seems to me that the model assumes only 1 dose of infusion and this infusion should stop before the plasma sampling. I would be grateful if you can me explain more details or write where I can find the details.
I can compute the AUC but don't know what to do with Vd and Cl.
There are the data for a patient:
Id Time Concentration
1 29.08333 13
1 31.08333 11
1 33.08333 11
1 37.08333 9
And the infusion details (the infusion actually started hours before, the time is the time since the start of it; the infusion does not stop, the length is the period between the two time points):
Id Time Length Dose
1 8.616667 21.13333 13.5
1 29.75 48.75 9
1 78.5 16.83333 4.5
When I run the NCA model 202, it seems to me that for each patient, the model uses only the last dose, which is actually after the last PK concentration sampling and so there are 0 points used and the model does not work.
I would appreciate any hints or ideas.
Edited by marie.simeckova, 16 April 2021 - 03:10 PM.