Problems with AUC calculation and dose simulation when using a steady-state model
#1
Posted 14 April 2021 - 09:24 AM
#3
Posted 15 April 2021 - 09:58 AM
There is one trick: you can reset AUC before dosing, e.g. using a dosepoint statement as follows:
dosepoint(Aa, dobefore={AUC=0})
Please see updated project file attached.
Bernd
Drug A._bwphxproj.phxproj 7.31MB 520 downloads
#4
Posted 18 April 2021 - 11:59 AM
how are you telling the solver that the ODE for AUC is at steady state ?
A straightforward solution is to simulate rich profile and do an nca
and in theory AUC0-tau at ss = AUC infinity = Dose/CL
so you can just compute the model based AUC0-24 at ss
Thank you for your reply! I have tried the way as you suggested. It does work.
#5
Posted 18 April 2021 - 12:05 PM
There is one trick: you can reset AUC before dosing, e.g. using a dosepoint statement as follows:
dosepoint(Aa, dobefore={AUC=0})
Please see updated project file attached.
Bernd
It's a brilliant method and is time-saving when the work of data analysis is heavy. Many thanks.
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