I was doing PopPK modelling for a clinical trial data. In this I first get a best fitted base model and then added covariates and found gender and weight showing significant effect over Vd. Bootstraping clearly supported my final model and VPC simulations also did so.
I have this manuscript under revision and reviewer asked me to run simulations at different dosing before commenting covariate effect on final model.
As i understand VPC simulations are on the same dosing and on the same weight participants. So, the question is how to run population simulations with random covariates with the original dosing (6 mg/kg single oral dose) and different dosing (12 mg/kg and 18 mg/kg). and how to interpret those results as discussion.
here i am attaching my project along with dosing sheet. Any help would be highly appreciated.